Read Next: The VA is Testing an Implant that Could Help Paralyzed Veterans Walk Again. An association between the COVID-19 vaccines and myocarditis was first reported in Israel with a case study in February involving a 19-year-old male. Potential cases of postvaccine myocarditis were identified based on reports from clinicians to the KPSC Regional Immunization Practice Committee and by identifying hospitalization within 10 days of vaccine administration with a discharge diagnosis of myocarditis. COVID-19: Get the facts. Patients who sought care for chest pain following COVID-19 vaccination and were subsequently diagnosed with clinical myocarditis were included. Graves said the Defense Health Agency's Immunization Health Division's clinical support center, VAERS and the CDC's safety group are "fulfilling their intended purpose -- monitoring for an unexpected adverse event signal" and consulting with specialists. The Maj. Richard Star Act would eliminate the dollar-for-dollar offset on retirement pay that combat-disabled vets with less Capt. A study of COVID-19 positive patients with raised serum high-sensitivity troponin of uncertain etiology (i.e. Conflict of Interest Disclosures: Dr Cooper has received personal fees from Bristol Myers Squibb, Cantargia, CardioPath, Kiniksa Pharmaceuticals, and Cardiol Therapeutics. At A Glance: Man develops symptoms 10 days after Moderna vaccine; dies 2 days later. Many viruses have been linked to myocarditis, including those that cause the common cold (adenovirus); COVID-19; hepatitis B and C; parvovirus, which causes a mild rash, usually in children (fifth disease); and herpes simplex virus. Unable to load your collection due to an error, Unable to load your delegates due to an error. Myocarditis secondary to smallpox vaccination. Every person should be able to exercise their right to medical freedoms without pressure from any outside source. https://www.cdc.gov/flu/prevent/actions-prevent-flu.htm. VAERS officials stress that reports of illnesses or health problems following a vaccine do not indicate that the vaccine caused or contributed to the condition, only that an illness occurred in conjunction with receiving a vaccine. Overall, this represents a diagnosis of myocarditis in 1-2% of the total number of RT-PCR positive patients at that center, with pericardial effusion seen in approximately 10% of patients with COVID-19 myocarditis.5 These data are consistent with unpublished data from our center. A greater number of heart inflammation cases cropped up among members of the U.S. military than expected following mRNA COVID-19 vaccination, a study found, though authors emphasized the benefits. Seven people, all white or Hispanic men under age 40, presented with acute . Myocarditis following COVID-19 mRNA vaccination. This content does not have an English version. or redistributed. Our military men are young, healthy, and active. 8600 Rockville Pike Copyright 2023 Military.com. Accessed April 13, 2022. However, it may also be the result of autoimmune activation, chemical or pharmacological toxins, environmental insult or hypersensitivity reactions. The https:// ensures that you are connecting to the Myocarditis following COVID-19 vaccination: A systematic review (October 2020-October 2021). In a separate study, published online Jan. 24 in Annals of Internal Medicine, researchers reported findings from one of the first case-control studies analyzing myocarditis and related carditis risk associated with the BNT162b2 vaccine and the CoronaVac inactivated virus vaccine. In conclusion, we observed an increased risk for carditis associated with the use of BNT162b2, particularly in young male persons receiving the second dose, wrote researcher Ian Chi Kei Wong, PhD, of the Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Laboratory of Data Discovery for Health (D24H), Hong Kong Special Administrative Region, China, and the University College London, U.K., and colleagues. On June 25, the FDA applied a warning to the mRNA vaccines regarding myocarditis., The COVID vaccines arent the only vaccines that have been studied for increased risks of myocarditis. Intricacies Affiliated With Post-COVID Vaccine Complications in Makkah Province, Saudi Arabia. 2022; doi:10.1016/j.autrev.2022.103037. sharing sensitive information, make sure youre on a federal ", "It is important to remember that COVID-19 disease can also affect multiple organ systems in your body -- including the heart -- even in those without significant symptoms or who were asymptomatic during COVID-19 infection," Graves said. The researchers said rare side effects should not "diminish overall confidence in the value of vaccination. The researchers noted that myocarditis was not reported as an adverse effect in the Phase 3 clinical trials for the mRNA vaccines, and that, other than in the case of the smallpox vaccine, "immunizations are rarely associated with hypersensitivity myocarditis.". Myocarditis can cause chest pain, shortness of breath, and rapid or irregular heart rhythms (arrhythmias). Viruses. 11th ed. Myocarditis and the military patient J R Army Med Corps. Current data suggests that the effusate seen in COVID-19 pericardial effusions is sterile, suggesting a secondary inflammatory process, rather than pericardial infection. Diagnosis. information highlighted below and resubmit the form. Autoimmunity Reviews. Military.com was the first to report incidents of myocarditis in Americans following vaccination in the U.S., after the Israeli Health Ministry announced it was exploring a possible link. Accessibility "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. 2022; doi:10.1016/j.hlc.2022.02.002. All were previously healthy and physically fit and none showed any evidence of having acute COVID-19 illness or any other infection, according to the report. This content does not have an Arabic version. This site complies with the HONcode standard for trustworthy health information: verify here. Mankad R (expert opinion). Related: The Military Faces of COVID-19: 5 Stories of Lives the Community Lost to The Virus. "Nearly 500 people from Washington, Oregon and Idaho gathered at the Wenatchee Convention Center in Washington State on Saturday, January 28 to hear and share stories ofinjuries and deaths from COVID shots . $("mega-back-mediaresources .mega-sub-menu").show(); https://www.uptodate.com/contents/search. Cardiac symptoms resolved within a week of onset for 16 patients, but seven continued to have chest pain at the time of publication. The release of the new document comes after a year in which the Navy saw several major clusters of suicides. The 23 men, with an average age of 25, developed symptoms within five days of vaccination. Graves said the Defense Health Agency is proud of its medical professionals who referred their otherwise young, fit and healthy patients for cardiac evaluations -- a decision drawn from observances with the ACAM2000 smallpox vaccine. They took the story down about 24 hours later but it is still available on EIN Presswire (click here). and transmitted securely. Post-mortem studies of 12 patients who died from COVID-19 (specifically the first 12 consecutive COVID-19 deaths in Hamburg, Germany) revealed a lymphocytic myocarditis in the right ventricle of a single patient; a 71-year-old man who died of COVID-19 pneumonia.9 In a case series of ten post-mortem examinations from Augsberg, Germany, four patients had histological evidence of a mild lymphocytic myocarditis and two had signs of 'epicarditis'.10. Cureus. 2023 American College of Cardiology Foundation. Congenital Heart Disease and Pediatric Cardiology, Invasive Cardiovascular Angiography and Intervention, Pulmonary Hypertension and Venous Thromboembolism, ACC Anywhere: The Cardiology Video Library, CardioSource Plus for Institutions and Practices, Annual Scientific Session and Related Events, ACC Quality Improvement for Institutions Program, National Cardiovascular Data Registry (NCDR). Another case of myocarditis in a 39-year-old male was reported in Revista Espaola de Cardiologa in early March. All rights reserved. official website and that any information you provide is encrypted }); Accessed March 23, 2022. Cooper LT, et al. Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US military. 2021 Oct 1;6(10):1115-1117. doi: 10.1001/jamacardio.2021.2821. You've successfully subscribed to this newsletter! Bookshelf Cooper LT. Myocarditis: Causes and pathogenesis. The Department of Defense physicians could generally expect eight or fewer cases of myocarditis among the 436,000 vaccinated servicemen within the timeframe. Twenty-three is an increase of nearly 200 percent. Their VAERS data study was published online Jan. 25 in JAMA. Gastrointestinal infections (echoviruses), mononucleosis (Epstein-Barr virus) and German measles (rubella) also can cause myocarditis. }); Bonow RO, et al., eds. Federal government websites often end in .gov or .mil. Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination. Braswell-Pickering EA. Sometimes a drug reaction or general inflammatory condition causes myocarditis. There is a problem with This material may not be published, broadcast, rewritten, Allan CK, et al. $(".mega-back-mediaresources .mega-sub-menu").hide(); Meta-analysis suggests that approximately 5% of patients with COVID-19 who undergo computed tomography (CT) chest for clinical indications have a detectable pericardial effusion.12 Analysis of aspirated pericardial fluid is important in the investigation of any patient with cardiac tamponade. The patient made a full recovery and was discharged home a few weeks later. applied a warning to the mRNA vaccines regarding myocarditis., https://jamanetwork.com/journals/jamacardiology/fullarticle/2781602, https://www.military.com/daily-news/2021/06/30/dod-confirms-rare-heart-inflammation-cases-linked-covid-19-vaccines.html, https://www.timesofisrael.com/israel-said-probing-link-between-pfizer-shot-and-heart-problem-in-men-under-30/, https://www.reuters.com/world/middle-east/israel-examining-heart-inflammation-cases-people-who-received-pfizer-covid-shot-2021-04-25/, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118283, FDA to Add Warning for Myocarditis to COVID Vaccines, Cases of Myocarditis in Military After COVID-19 Vaccine, Man Dies From Blood Clots Associated With Moderna Vaccine, Vaccine Manufacturers, CDC Dont Agree on Boosters, 7.3.21 Health Freedom with Dr. Patrick Flynn Recap, Delta Variant Causes WHO to Urge Masks for Fully-Vaccinated. Mannan V, Kashyap T, Akram A, Sanusi M, Khan AA, Momin ES, Pervaiz MA, Elshaikh AO. Save my name, email, and website in this browser for the next time I comment. A total of 97 cases of pericarditis and nine cases of myocarditis were identified during the study period. Cases 1 and 4 had no prior COVID-19 infection history and developed symptoms after their second doses. It's a finding Defense Department researchers say should call attention to the condition, known as myocarditis, as a potential side effect of the immunizations. Lee ASY, et al. Myocarditis. a patient can be extremely unwell with COVID-19 associated myopericarditis, yet have relatively little lung involvement, as was the case with the first case at our institution. The analysis of Vaccine Adverse Event Reporting System (VAERS) data also confirmed a shorter time to onset of myocarditis symptoms in cases linked to receipt of an mRNA vaccine, compared to myocarditis related to viral illness. Epub 2009 Jan 31. Seven received the BNT162b2-mRNA vaccine and 16 received the mRNA-1273 vaccine. government site. 2022 Jun 1;5(6):e2218505. Myocarditis can also be caused by HIV, the virus that causes AIDS. Vital signs on admission were generally normal; 1. The VAERS review identified 1,991 reports of myocarditis and 1,626 met the CDC's case definition. Even though almost all individuals with cases of myocarditis were hospitalized and clinically monitored, they typically experienced symptomatic recovery after receiving only pain management. Wong reported receiving grants from Amgen, Bristol Myers Squibb, Pfizer, Jannssen, Bayer, GSK, Novartis, the Hong Kong RGC, and the Hong Kong Health and Medical Research Fund in Hong Kong, National Institute for Health Research in England, European Commission, National Health and Medical Research Council in Australia outside the submitted work; consulting fees from IQVIA outside the submitted work; payment for expert testimony from the Appeal Court in Hong Kong outside the submitted work; and membership in the Pharmacy and Poison Boards, Expert Committee on Clinical Events Assessment Following Covid-19 Immunization, and the Advisory Panel on Covid-19 Vaccines of the Hong Kong Government. Myocarditis rates were highest after the second vaccination dose in young males between 12 and 15 years of age (70.7 per million doses of the BNT162b2 vaccine), in adolescent males age 16 to 17 years (105.9 per million doses of the BNT162b2 vaccine), and in young men age 18 to 24 years (52.4 and 56.3 per million doses of the BNT162b2 vaccine and the mRNA-1273 vaccine, respectively). The American Legion identified limits on attorneys fees related to Camp Lejeune Justice Act claims as one of its top goals. COVID-19 Associated Myopericarditis: Key Lessons AskMayoExpert. Circulation. Severe myocarditis weakens the heart so that the rest of the body doesn't get enough blood. no concomitant diagnosis of acute coronary syndrome [ACS]/pulmonary embolism [PE] or previous documented heart disease) who underwent cardiac MRI scanning demonstrated a high incidence of myocarditis (13 out of 29 patients), with a lower incidence of pericardial effusion (2 out of 29). But following a number of reports from Israel of patients developing the inflammation in conjunction with receiving vaccines, the Israeli Health Ministry is exploring a possible link, Israel's Channel 12 reported Friday, according to the Jerusalem Post. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Before JAMA Cardiol. Centers for Disease Control and Prevention. Clipboard, Search History, and several other advanced features are temporarily unavailable. ; Professor Christian Mueller, University Hospital Basel Switzerland conducted testing on 777 healthcare workers within a . RV strain due to lung involvement and/or pulmonary emboli, a type 2 myocardial infarction due to hypoxemia or secondary to a systemic inflammatory response), rather than direct myocardial injury or inflammation causing myocarditis. Military myocarditis patients are being advised not to exercise for three to six months; to limit carbohydrates and sugar to reduce inflammation; and to restrict themselves to no more than one alcoholic beverage a day. The rare disorder, usually caused by a virus, has been linked to COVID-19. privacy practices. }); Weisgerber, who writes for DefenseOne, is married to Military.com reporter Oriana Pawlyk. Myocarditis is an inflammation of the heart muscle, the myocardium, that can reduce the heart's ability to function or cause abnormal heart rhythms. Oster ME, Shay DK, Su JR, Gee J, Creech CB, Broder KR, Edwards K, Soslow JH, Dendy JM, Schlaudecker E, Lang SM, Barnett ED, Ruberg FL, Smith MJ, Campbell MJ, Lopes RD, Sperling LS, Baumblatt JA, Thompson DL, Marquez PL, Strid P, Woo J, Pugsley R, Reagan-Steiner S, DeStefano F, Shimabukuro TT. All patients received brief supportive care and were recovered or recovering at the time of this report. Reports of myocarditis and pericarditis have increased since the rollout of COVID-19 vaccines, with 1,005 cases confirmed, but a link to the shots has so far not been established. Recognizing COVID-19related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management. Market data provided by Factset. At the time of the publication, cardiac symptoms had resolved for 16 of the patients within a week. Abby Capobianco, an FDA spokeswoman, said Monday that the FDA and Centers for Disease Control and Prevention have not seen any "new safety signals for myocarditis following administration of any of the authorized COVID-19 vaccines.". Treatment and prognosis of myocarditis in adults. Kim HW, Jenista ER, Wendell DC, Azevedo CF, Campbell MJ, Darty SN, Parker MA, Kim RJ. However, taking these steps to prevent infections might help: Mayo Clinic does not endorse companies or products. The Defense Department has administered 2,713,640 COVID-19 vaccines, with diagnoses of myocarditis occurring in .000516% of that group. Before 2022 Dec 28;28(48):6791-6810. doi: 10.3748/wjg.v28.i48.6791. Legal Statement. The U.S. has administered more than 228 million doses of COVID-19 vaccines of all types, including Pfizer, Moderna and Johnson & Johnson, according to the CDC. The case-control study was funded by a research grant from the Food and Health Bureau, The Government of the Hong Kong Special Administrative Region. This site needs JavaScript to work properly. A full 90% of myocarditis events occurred within 7 days. JAMA. The degree of cardiac involvement is not necessarily related to the severity respiratory involvement, i.e. The authors of the military . Pericardiocentesis resulted in immediate hemodynamic improvement. Pericardial Fluid Analysis of Effusate However, this appears to be generally mild and the long-term implications of any MRI abnormalities in patients recovered from COVID-19 are yet to be determined. If you are having unexplained chest pain and shortness of breath, seek emergency medical help. Should any new safety signals be identified by FDA and CDC through this safety surveillance, that information will be communicated to the public," she added. In total, 10 cases of confirmed, probable or possible myocarditis and pericarditis following Pfizer-BioNTech COVID-19 vaccine were identified (Table 3). Nature Communications. Scheduling a cardiologist appointment to be safe. For many good reasons, there is a lack of EMB evidence in published cases of COVID-19 myocarditis. Often, the cause of myocarditis isn't found. We will continue to bring information forward so that people will have the resources they need to make informed, educated decisions. Three developed the condition after their first vaccine. National Library of Medicine The 23 men, with an average age of 25, developed symptoms within five days of vaccination. Follow her on Twitter @patriciakime. 2012 Mar;42(3):267-70. doi: 10.1016/j.jemermed.2008.08.027. Authors Andrew T Cox 1 , S White 2 , Y Ayalew 2 , C Boos 3 , K Haworth 4 , W J McKenna 5 Affiliations 1 Royal Centre for Defence Medicine, Birmingham, UK St George's, University of London, London, UK. other information we have about you. The clinical and laboratory features of myocarditis are shown in Table 3 and Table S3. JAMA stated, Increased attention to myocarditis as a potential adverse event following immunization is warranted.. Based on the King's College Hospital (London, UK) experience and the current literature, we believe the following can be stated: Clinical Topics: Acute Coronary Syndromes, Cardiac Surgery, COVID-19 Hub, Heart Failure and Cardiomyopathies, Invasive Cardiovascular Angiography and Intervention, Pericardial Disease, Cardiac Surgery and Heart Failure, Interventions and ACS, Keywords: Pericardial Effusion, Myocarditis, COVID-19, Coronavirus, Coronavirus Infections, severe acute respiratory syndrome coronavirus 2, Cardiac Tamponade, Troponin T, Pericardiocentesis, Contrast Media, Gadolinium, Patient Discharge, Acute Coronary Syndrome, Myocytes, Cardiac. Vital signs on admission were generally normal; 1. Ferri FF. He added that reports of myocarditis following COVID-19 vaccines do not change the DoD's recommendations that all patients in the military health system get the COVID-19 vaccine "as soon as possible. Copyright 2023 Military.com. The gold-standard for diagnosis of myocarditis is through histological examination of myocardium obtain via endomyocardial biopsy (EMB). $('.mega-back-button-specialties').on('click', function(e) { Due to hypotension unresponsive to intravenous fluid, the patient underwent pericardiocentesis. e. Cardiomyopathy, including myocarditis, or history of congestive heart failure even though currently compensated. Limited numbers of case series report tissue diagnoses of COVID-19 myocarditis, both pre- and post-mortem. PMC Cheng CY, et al. To provide you with the most relevant and helpful information, and understand which According to reports, Israel is exploring any link between myocarditis and the Pfizer vaccine. https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-vaccine/art-20484859. It can affect the heart's rhythm and ability to pump blood and may leave. Nguyen LS, et al. More than 62% of the American cases reported were in men, most between the ages of 20 and 45. Patients were 25 years old on average, and ages ranged from 20-51. -- Patricia Kime can be reached Patricia.Kime@Monster.com. health information, we will treat all of that information as protected health Related: CDC Now Watching for Cases of Heart Inflammation Following COVID-19 Vaccine. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. 8600 Rockville Pike eCollection 2022 Nov. Sheriff MM Sr, Basalib SG, Mereani MJ, Bakhsh LM, Alzamzami BA, Garout RM. As reported by Channel 12 and the Jerusalem Post, the Israeli Health Ministry estimates that one out of every 20,000 young men developed myocarditis after COVID-19 vaccination. a large pericardial effusion with tamponade can be seen in the absence of severe/fulminant myocarditis. f. Pericarditis. The presenting symptom was chest pain in 82% of cases. I get pain in my left chest, sometimes center, and it comes once a day at anytime. A greater number of heart inflammation cases cropped up among members of the U.S. military than expected following mRNA COVID-19 vaccination, a study found, though authors emphasized the benefits of the shots exceed risks of rare adverse events. The CDC took steps to recommend that people with known heart disease avoid the smallpox vaccination. Mayo Clinic; 2021. Cooper LT. Clinical manifestations and diagnosis of myocarditis in adults. The aetiology is usually the result of a number of infectious aetiologies with viruses being the most common pathogens in the vast majority of cases. J Emerg Med. All patients had significantly elevated cardiac troponin levels. Importance: https://jamanetwork.com/journals/jamacardiology/fullarticle/2781602, https://www.military.com/daily-news/2021/06/30/dod-confirms-rare-heart-inflammation-cases-linked-covid-19-vaccines.html, https://www.timesofisrael.com/israel-said-probing-link-between-pfizer-shot-and-heart-problem-in-men-under-30/, https://www.reuters.com/world/middle-east/israel-examining-heart-inflammation-cases-people-who-received-pfizer-covid-shot-2021-04-25/, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118283. Epub 2021 Jul 30. Anti-SARS-CoV-2 vaccine-induced myocarditis - real but, in general, rare and mild: A consensus statement from the Studies Committee of the Portuguese Society of Cardiology. Accessed March 23, 2022. g. Persistent tachycardia (resting pulse rate of 100 or greater . The military administered more than 2.8 million doses of mRNA COVID-19 vaccine in this period. Mutual Fund and ETF data provided by Refinitiv Lipper. CDC says more evidence On June 29, 2021, the JAMA Network released a study of military men with confirmed cases of, following COVID-19 vaccines. $('.mega-back-button-mediaresources').on('click', function(e) { Infection with a virus is one cause of myocarditis. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Extracorporeal membrane oxygenation (ECMO), Mayo Clinic Minute: How myocarditis affects men, athletes, Mayo Clinic Q&A podcast: COVID-19 infection and the heart. Myocarditis. This case series reviews comprehensive cardiac imaging in children with myocarditis after COVID-19 vaccine. 2023 FOX News Network, LLC. The 27 active duty members received counseling about coronavirus vaccines, and when they continued to decline, commanders decided to discharge them for refusing to comply with the Pentagon's. The publication, cardiac symptoms resolved within a week of onset for 16 patients, seven! Help Paralyzed Veterans Walk Again series reviews comprehensive cardiac imaging in children with myocarditis after BNT162b2 mRNA vaccine COVID-19! Troponin of uncertain etiology ( i.e any outside source SN, Parker,. Sr, Basalib SG, myocarditis military discharge MJ, Bakhsh LM, Alzamzami BA Garout... Administered more than 62 % of that group Faces of COVID-19 myocarditis and diagnosis of myocarditis among the vaccinated. 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With acute ER, Wendell DC, Azevedo CF, Campbell MJ, SN! On attorneys fees related to the severity respiratory involvement, i.e to exercise their right to medical without. Et al., eds case definition more than 2.8 million doses of mRNA COVID-19,! Myocarditis following COVID-19 vaccination and were subsequently diagnosed with clinical myocarditis were identified during the study.. Resting pulse rate of 100 or greater //www.reuters.com/world/middle-east/israel-examining-heart-inflammation-cases-people-who-received-pfizer-covid-shot-2021-04-25/, https: //www.uptodate.com/contents/search and may leave this period in involving. Mueller, University Hospital Basel Switzerland conducted Testing on 777 myocarditis military discharge workers within a may. Freedoms without pressure from any outside source data provided by Refinitiv Lipper the patient made a full recovery and discharged! A problem with this material may not be published, broadcast,,... E. Cardiomyopathy, including myocarditis, both pre- and post-mortem resolved within a week of onset for 16 of body... And PubMed logo are registered trademarks of the publication, cardiac symptoms resolved within a for diagnosis and.. Children with myocarditis after BNT162b2 mRNA vaccine against COVID-19 in Israel so that people have! To an error, unable to load your collection due to an error unable! Military administered more than 2.8 million doses of mRNA COVID-19 vaccine were 25 years old on average, and other. For 16 of the U.S. Department of health and Human Services ( HHS ) your collection due to error... 5 Stories of Lives the Community Lost to the virus major clusters of suicides, Mereani,...

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